TRANSLATIONAL PHYSIOLOGY Diesel exhaust activates redox-sensitive transcription factors and kinases in human airways
نویسندگان
چکیده
Jamshid Pourazar,* Ian S. Mudway,* James M. Samet, Ragnberth Helleday, Anders Blomberg, Susan J. Wilson, Anthony J. Frew, Frank J. Kelly, and Thomas Sandström Department of Respiratory Medicine and Allergy, University Hospital, Umeå, Sweden; Lung Biology, School of Health and Life Sciences, King’s College London, London, United Kingdom; Human Studies Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Chapel Hill, North Carolina; and Allergy and Inflammation Research, School of Medicine, University of Southampton, Southampton, United Kingdom
منابع مشابه
Diesel exhaust activates redox-sensitive transcription factors and kinases in human airways.
Diesel exhaust (DE) is a major component of airborne particulate matter. In previous studies we have described the acute inflammatory response of the human airway to inhaled DE. This was characterized by neutrophil, mast cell, and lymphocyte infiltration into the bronchial mucosa with enhanced epithelial expression of IL-8, Gro-alpha, and IL-13. In the present study, we investigated whether red...
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We have previously demonstrated that short-term exposure to diesel exhaust (DE) for 1 h induced a marked leukocytic infiltration in the airways of healthy human volunteers involving neutrophils, lymphocytes, and mast cells along with increases in several inflammatory mediators. We hypothesized that the leukocyte infiltration and the various inflammatory responses induced by DE were mediated by ...
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The primary role of pulmonary airways is to conduct air to the alveolar epithelium, where gas exchange can efficiently occur. Injuries to airways resulting from inhalation of airborne pollutants and parenteral exposure to ingested pollutants that cause oxidative stress have the potential to interfere with this process. A progressive rise of oxidative stress due to altered reduction-oxidation (r...
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Fine particles derived from diesel engines, diesel exhaust particles (DEP), have been shown to augment gene expression of several inflammatory cytokines in human airway epithelial cells in vitro. However, it remains unclear whether or not DEP have any effect on the expression and production of eotaxin, an important chemokine involved in eosinophil recruitment into the airways. We studied the ef...
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Background Asthma is a chronic condition described by inflammation of the airways and lungs. Diesel exhaust (DE) is a major contributor to ambient particulate matter (PM) air pollution. There is rising evidence that PM acts as adjuvant on the immune responses and may lead to augmentation of allergic inflammation [1,2]. We aim to elucidate if DE increases allergen-induced inflammation and cellul...
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